Big Ten Conference | Away
Oregon vs Michigan State
Saturday, Nov 21, 2026 | Spartan Stadium, East Lansing
TV: TBD | Kickoff: TBD
Michigan State 2025: 4-8
Prediction: Medium-High
Last: W 31-10 (2024)
| Sources: GoDucks.com, 247Sports
Derrick Harmon transferred from Michigan State to Oregon in 2024 and became a first-round draft pick (Steelers, #21 overall). That still stings in East Lansing. Jonathan Smith was fired after going 4-15 in two seasons. Pat Fitzgerald, the former Northwestern coach (110 wins in 17 seasons), took over in December 2025 and is rebuilding from scratch. Oregon won 31-10 in 2024 and should handle this, but late November in East Lansing is cold, hostile, and unpredictable.

Key Matchups

November football in the Big Ten
Cold weather, grass field, hostile crowd. Oregon is a West Coast team playing in Midwest November conditions. The run game and defense travel. The passing game can struggle in wind and cold.
Coaching matchup
Pat Fitzgerald brings Northwestern toughness and defensive discipline to Michigan State. His teams at Northwestern were always hard to prepare for. However, a first-year coach in East Lansing with a thin roster is a different challenge. Trap game potential is real with Washington the following week.

Michigan State Snapshot

Michigan State 2025: 4-8 Coach: Pat Fitzgerald All-time: 5-3 (Oregon leads)

What to Watch

Weather. If it is 30 degrees and windy, Oregon's passing game adjustments matter. Also: can Oregon stay focused with the Washington rivalry game the following week? The coaching staff must keep eyes forward.

Ducks vs Them: Michigan State

2024
Ducks vs Them: Oregon vs Michigan State
The official pregame hype video from Oregon Athletics. W 31-10.
Via GoDucks / Oregon Athletics

Score Prediction

Medium-High Confidence
Oregon 31, Michigan State 14
Oregon is more talented but late November road games in the Big Ten are never easy. The weather and the rivalry week distraction could keep it closer than expected in the first half.
How to Watch
TBD
TV Channel
TBD
Kickoff
On the schedule: Washington rivalry finale next week | Coming off Michigan at Autzen

Pre-season analysis. Predictions are for entertainment. Coach: Pat Fitzgerald.

Frequently Asked Questions

Oregon plays at Michigan State on Saturday, November 21, 2026 at Spartan Stadium in East Lansing, Michigan. It is Oregon's penultimate regular season game before the Washington rivalry finale.

Pat Fitzgerald, hired December 1, 2025 on a five-year deal. Fitzgerald previously compiled 110 wins and 65 Big Ten wins in 17 seasons at Northwestern. He replaced Jonathan Smith, who was fired after going 4-8 in 2025.

Yes. Defensive tackle Derrick Harmon spent three seasons at Michigan State before transferring to Oregon in 2024. He anchored Oregon's defensive line during the 13-0 Big Ten championship run and was drafted #21 overall by the Pittsburgh Steelers in 2025.

Oregon leads the all-time series 5-3. Oregon has won 2 straight (2018, 2024). The series dates back to 1972. Series record per Winsipedia (April 2026).

The Harmon revenge game. What is your score prediction?

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